TIC occurs after severe tissue injury

Tissue injury measured by Injury Severity Score (ISS) is correlated with PT-based (0.14, p< 0.001) and PTT-based coagulopathy (0.23, p<0.001)

Coagulopathy is associated with combination of tissue hypoperfusion and tissue injury in a mice model

Coagulopathy developed in rats subjected to haemorrhagic shock and tissue perfusion.

Tissue injury, measured by Injury Severity Score (ISS), is strongly associated with coagulopathy.

Patients with severe tissue injury but no physiologic derangement rarely present with a coagulopathy. Tissue trauma is, therefore, an initiator of coagulation, but in isolation is rarely responsible for clinical coagulopathy.